Chemogenetic Recruitment of Specific Interneurons Suppresses Seizure Activity
نویسندگان
چکیده
منابع مشابه
Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons.
A variety of epileptic seizure models have shown that activation of glutamatergic pyramidal cells is usually required for rhythm generation and/or synchronization in hippocampal seizure-like oscillations in vitro. However, it still remains unclear whether GABAergic interneurons may be able to drive the seizure-like oscillations without glutamatergic transmission. Here, we found that electrical ...
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متن کاملModification of Seizure Activity
Repeated electrical stimulation of certain brain areas in the rat can decrease thresholds for epileptiform after-discharge (AD) in those areas (Racine 1972). Motor seizures, which cannot initially be evoked by electrical stimulation of subcortical nuclei in the rat, can also be developed by daily electrical stimulation via implanted electrodes (Goddard et al. 1969). Goddard et al., however, rec...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2018
ISSN: 1662-5102
DOI: 10.3389/fncel.2018.00293